Abstract
To improve the treatment outcomes for large bone defects and osteoporosis, researchers have been committed to reducing bone loss and accelerating bone regeneration through cell transplantation, biomaterial intervention, and biophysical stimulation over the past few decades. Magnetism, as a noninvasive biophysical stimulus, has been employed in the repair of the musculoskeletal system, achieving a series of promising results. In this review, we provide a retrospective analysis and perspective of research on magnetic-driven bone regeneration and functional reconstruction. This review aims to delineate safe and efficient magnetic application modalities and to summarize the potential mechanisms by which magnetism regulates the behavior of skeletal lineage cells, thereby providing insights for the expansion and translational application of magnetic-driven regenerative medicine.