Antibodies to an interfering epitope in hepatitis C virus E2 can mask vaccine-induced neutralizing activity
丙型肝炎病毒 E2 干扰表位的抗体可以掩盖疫苗诱导的中和活性
阅读：28
作者：Alla Kachko, Sharon E Frey, Lev Sirota, Ranjit Ray, Frances Wells, Iryna Zubkova, Pei Zhang, Marian E Major
| 期刊： | Hepatology | 影响因子： | 12.900 |
| 时间： | 2015 | 起止号： | 2015 Dec;62(6):1670-82. |
| doi： | 10.1002/hep.28108 | 研究方向： | 免疫、微生物学 |
| 疾病类型： | 肝炎 | |
Conclusion
These data show that antibodies to the region 434-446 are induced during immunization of individuals with recombinant E1E2 proteins, and that these antibodies can mask effective neutralizing activity from EP-I-specific antibodies. Elicitation of EP-II-specific antibodies with interfering capacity should be avoided in producing an effective cross-neutralizing vaccine aimed at the HCV envelope proteins.
Trial registration
ClinicalTrials.gov NCT00500747.
特别声明
1、本页面内容包含部分的内容是基于公开信息的合理引用；引用内容仅为补充信息，不代表本站立场。
2、若认为本页面引用内容涉及侵权，请及时与本站联系，我们将第一时间处理。
3、其他媒体/个人如需使用本页面原创内容，需注明“来源：[生知库]”并获得授权；使用引用内容的，需自行联系原作者获得许可。
4、投稿及合作请联系：info@biocloudy.com。
