Abstract
BACKGROUND: Vesicular rashes are associated with a variety of infectious and noninfectious causes. OBJECTIVE: To discuss the differential diagnoses of vesicular rashes. METHODS: We present the clinical case of an adult woman who was immunocompetent and who developed several clear fluid-filled vesicles on her upper extremity within days of receiving the varicella zoster vaccine. Over the next several days, the skin eruption generalized, and she developed new lesions in various stages of healing. RESULTS: After a detailed history and further studies were obtained, a final diagnosis was made. CONCLUSION: In patients who have recently been vaccinated, a high index of suspicion for an adverse vaccine reaction should be maintained.