Abstract
The sterile inflammatory response observed after hepatic necrosis caused by an acetaminophen (APAP) overdose has been a controversial topic for years. In a recent review, Gong et al. (2021) provided a list of studies investigating the mechanisms of inflammation during APAP-induced injury and recovery as well as those using natural products as anti-inflammatory intervention strategies in this context. However, the review lacks a critical assessment of the cited literature, which leads to the amplification of questionable mechanistic conclusions. We feel it is necessary to express our concerns regarding such superficial reviews of a scientific field, which hamper progress and are not helpful in advancing the field.