On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin

利用芯片筛选C型凝集素糖模拟文库，揭示了Dectin-2优先于DC-SIGN/R和Langerin结合的结构特征。

阅读：1
作者：Medve,Laura,Achilli,Silvia,Serna,Sonia,Zuccotto,Fabio,Varga,Norbert,Thépaut,Michel,Civera,Monica,Vivès,Corinne,Fieschi,Franck,Reichardt,Niels,Bernardi,Anna
期刊：Chemistry-A European Journal影响因子：3.700
时间：2018起止号：2018 Sep 25;24(54):14448-14460
doi：10.1002/chem.201802577

Abstract

A library of mannose- and fucose-based glycomimetics was synthesized and screened in a microarray format against a set of C-type lectin receptors (CLRs) that included DC-SIGN, DC-SIGNR, langerin, and dectin-2. Glycomimetic ligands able to interact with dectin-2 were identified for the first time. Comparative analysis of binding profiles allowed their selectivity against other CLRs to be probed.

特别声明

1、本页面内容包含部分的内容是基于公开信息的合理引用；引用内容仅为补充信息，不代表本站立场。

2、若认为本页面引用内容涉及侵权，请及时与本站联系，我们将第一时间处理。

3、其他媒体/个人如需使用本页面原创内容，需注明“来源：[生知库]”并获得授权；使用引用内容的，需自行联系原作者获得许可。

4、投稿及合作请联系：info@biocloudy.com。