Abstract
Post-cardiac injury syndrome (PCIS) is an underrecognized inflammatory complication of atrial fibrillation ablation that can mimic acute coronary syndrome. We present a 72-year-old man who developed pleuritic chest pain and pleural effusions 3 days after radiofrequency ablation. Using the 2025 European Society of Cardiology diagnostic criteria, we identified pleural-predominant PCIS. Anti-inflammatory treatment led to rapid recovery.