Abstract
OBJECTIVE: To analyze the effect of interventional surgery on treatment efficacy and inflammatory cytokine (ICK) levels in diabetic patients with peripheral vascular disease (PVD). METHODS: A total of 116 diabetic patients with PVD admitted to the Second Affiliated Hospital of Guangzhou Medical University from August 2020 to March 2022 were selected for this retrospective analysis. Patients were divided into two groups: 58 patients receiving conventional medication were assigned to the control group, while 58 patients receiving interventional surgery in addition to conventional medication were assigned to the research group. Comparative analyses were conducted based on clinical efficacy, symptom relief (limb pain, numbness, intermittent claudication, and coldness), ankle-brachial index (ABI) scores, vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β), arterial inner diameter, and ICK levels. RESULTS: The research group demonstrated a significantly higher overall effective rate compared to the control group, with markedly higher ABI scores, faster symptom resolution, increased VEGF and TGF-β levels, greater arterial diameters, and lower ICK levels. CONCLUSION: Interventional surgery provides superior outcomes compared to conventional medication for treating diabetic patients with PVD, offering greater benefits in terms of ABI improvement, symptom relief, vascular factors, arterial diameter expansion, and ICK reduction.