Abstract
Castleman's disease (CD) is a rare benign lymphoproliferative disorder. We are presenting three cases of CD of which one is unicentric CD, and the other two are an idiopathic multicentric CD. One of the two multicentric cases is associated with POEMS syndrome. The whole body (18)F-Fluorodeoxyglucose positron-emission tomography-computed tomography scan plays a significant role in identifying the centricity, distribution of disease, response to therapy, and in early detection of remission.