Abstract
This systematic review investigates the effect of curcumin on neurocognitive exams and inflammatory serum biomarkers in adults 18 years and older. We search PubMed, Science Direct, Google Scholar, Cochrane Library, and Multidisciplinary Digital Publishing Institute. Modeling the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA), we screened 1,284 studies with the keywords "neurocognitive disorders," "dementia," "cognitive health," "serum biomarkers," and "curcumin." We use the revised Cochrane Risk-of-Bias tool (RoB2) and the Newcastle-Ottawa Scale to select 12 open-access full-text articles published within 20 years. We include clinical trials, randomized controlled trials (RCTs), cohort studies, and human studies, excluding nonhumans, other design types, and schizophrenia. Despite gastrointestinal side effects, studies found curcumin significantly improves working memory in the following adult groups: non-demented, metabolically impaired, cognitively impaired, mood impaired, and chemotherapy impaired. Study limitations include variable population characteristics and few trials employing intention-to-treat analysis, emphasizing the need for shared clinical decision-making before curcumin therapy.