Abstract
BACKGROUND: Acute bronchiolitis and air pollution are both risk factor of pediatric asthma. This study aimed to assess subsequent exposure to air pollutants related to the inception of preschool asthma in infants with acute bronchiolitis. This study aimed to assess subsequent exposure to air pollutants related to the inception of preschool asthma in infants with acute bronchiolitis. METHODS: A nested case-control retrospective study was performed at the Kaohsiung Medical University Hospital systems between 2009 and 2019. The average concentration of PM(10), PM(2.5), SO(2), NO, NO(2,) and NO(X) was collected for three, six, and twelve months after the first infected episode. Adjusted regression models were employed to evaluate the association between asthma and air pollution exposure after bronchiolitis. RESULTS: Two thousand six hundred thirty-seven children with acute bronchiolitis were included. Exposure to PM(10), PM(2.5), SO(2), NO, NO(2,) and NO(X) in the three, six, and twelve months following an episode of bronchiolitis was found to significantly increase the risk of preschool asthma in infants with a history of bronchiolitis.(OR, 95%CI: PM(10) = 1.517-1.559, 1.354-1.744; PM(2.5) = 2.510-2.603, 2.148-3.061; SO(2) = 1.970-2.040, 1.724-2.342; ; NO = 1.915-1.950, 1.647-2.272; NO(2) = 1.915-1.950, 1.647-2.272; NO(X) = 1.752-1.970, 1.508-2.252) In a sensitive analysis of hospitalized infants, only PM(10), PM(2.5), SO(2,) and NO were found to have significant effects during all time periods. (OR, 95%CI: PM(10) = 1.613-1.650, 1.240-2.140; PM(2.5) = 2.208-2.286, 1.568-3.061; SO(2) = 1.679-1.622, 1.197-2.292; NO = 1.525-1.557, 1.094-2.181) CONCLUSION: The presence of ambient PM(10), PM(2.5), SO(2) and NO in the three, six, and twelve months following an episode of acute bronchiolitis has been linked to the development of preschool asthma in infants with a history of acute bronchiolitis.