Conclusions
These results suggest that the TZAP mutation is a possible prognostic marker in BC.
Methods
We analyzed the TZAP mutation in 128 breast carcinomas (BCs). In addition, its association with telomere length was investigated.
Results
The TZAP mutation (c.1272 G > A, L424L) was found in 7.8% (10/128) of the BCs and was associated with the N0 stage. BCs with the TZAP mutation had longer telomeres than those without this mutation. Survival analysis showed that the TZAP mutation resulted in poorer overall survival. Conclusions: These results suggest that the TZAP mutation is a possible prognostic marker in BC.