Shorter exposures to harder X-rays trigger early apoptotic events in Xenopus laevis embryos

较短时间暴露于强度更高的 X 射线会引发非洲爪蟾胚胎的早期凋亡事件

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作者:JiaJia Dong, Sean P Mury, Karen E Drahos, Marko Moscovitch, Royce K P Zia, Carla V Finkielstein

Background

A long-standing conventional view of radiation-induced apoptosis is that increased exposure

Significance

Overall, our data establish that the energy of the incident photon is a major contributor to the outcome of the biological system. In particular, for embryos exposed under identical conditions and delivered the same absorbed dose of radiation, the response is significantly increased when shorter bursts of more energetic photons are used. These results suggest that biological organisms display properties similar to the photoelectric effect in physical systems and provide new insights into how radiation-mediated apoptosis should be understood and utilized for therapeutic purposes.

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