Insufficient SIRT1 in macrophages promotes oxidative stress and inflammation during scarring
巨噬细胞中 SIRT1 不足会促进疤痕形成过程中的氧化应激和炎症
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作者：Ting He #, Xiaozhi Bai #, Yan Li, Dongliang Zhang, Zhigang Xu, Xuekang Yang, Dahai Hu, Juntao Han
Key messages
SIRT1 was suppressed in scar while increased in macrophages of scar tissue. Inhibition of SIRT1 in macrophage leads to further activated oxidative stress. SIRT1 is negatively related to oxidative stress in macrophage. The elevation of SIRT1 in macrophage is insufficient during scarring.
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