Effects of low-dose aspirin and fish oil on platelet function and NF-kappaB in adults with diabetes mellitus

低剂量阿司匹林和鱼油对糖尿病成人患者血小板功能和 NF-κB 的影响

阅读：8

作者：Robert C Block, Amir Abdolahi, Brian Smith, N Meednu, Kelly Thevenet-Morrison, Xueya Cai, Huadong Cui, Shaker Mousa, J Thomas Brenna, S Georas

期刊：

Prostaglandins Leukotrienes and Essential Fatty Acids

影响因子：

2.900

时间：

2013

起止号：

2013 Jul;89(1):9-18.

doi：

10.1016/j.plefa.2013.03.005

研究方向：

代谢

疾病类型：

糖尿病

细胞类型：

血小板

信号通路：

NF-κB

Conclusions

Co-administration of aspirin and fish oil may reduce platelet aggregation more than aspirin alone in adults with diabetes mellitus.

Methods

Thirty adults with type 2 diabetes mellitus were treated with aspirin 81 mg/d for 7 days, then with fish oil 4 g/day for 28 days, then the combination of fish oil and aspirin for another 7 days.

Results

Aspirin alone and in combination with fish oil reduced platelet aggregation in most participants. Five of 7 participants classified as aspirin insensitive 1 week after daily aspirin ingestion were sensitive after the combination. Although some platelet aggregation measures correlated positively after aspirin and fish oil ingestion alone and (in combination) in all individuals, correlation was only observed in those who were aspirin insensitive after ingestion of the combination. Conclusions: Co-administration of aspirin and fish oil may reduce platelet aggregation more than aspirin alone in adults with diabetes mellitus.

Trial registration

ClinicalTrials.gov NCT01181882.