Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis"

关于“神经退行性疾病对人类成年海马神经发生的影响”的评论

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作者:Arturo Alvarez-Buylla, Arantxa Cebrian-Silla, Shawn F Sorrells, Marcos Assis Nascimento, Mercedes F Paredes, Jose Manuel Garcia-Verdugo, Zhengang Yang, Eric J Huang

Abstract

Terreros-Roncal et al. investigated the impacts of human neurodegeneration on immunostainings assumed to be associated with neurogenesis. However, the study provides no evidence that putative proliferating cells are linked to neurogenesis, that multipolar nestin+ astrocytes are progenitors, or that mature-looking doublecortin+ neurons are adult-born. Their histology-marker expression differs from what is observed in species where adult hippocampal neurogenesis is well documented.

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