Self-renewal of hepatoblasts under chemically defined conditions by iterative growth factor and chemical screening

通过迭代生长因子和化学筛选实现化学定义条件下肝母细胞的自我更新

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作者:Linjie Lv, Qingwang Han, Yinghao Chu, Muzi Zhang, Lin Sun, Wanguo Wei, Caixia Jin, Wenlin Li

Conclusion

Our work established a chemically defined condition that allows long-term expansion of hepatoblasts, improved our understanding of hepatoblast self-renewal, and highlights the power of phenotypic screening to enable self-renewal of somatic stem/progenitor cells.

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