Conclusion
It can be concluded that the formation of atheroma plate in diabetics is caused by the oxidation of circulating lipoproteins by free radicals generated following hyperglycemia, which can be avoided by supplementing antioxidant molecules such as antioxidant vitamins, trace elements.
Methods
This research was carried out at the Bouguerra Boulaares hospital and Alia Salah hospital in Tebessa, Algeria, on 560 patients with type 2 diabetes (300 women and 260 men), compared with 100 normal subjects (50 women and 50 men). For all subjects the following parameters were estimated: blood pressure, BMI (body mass index), glucose, glycated hemoglobin, total cholesterol, HDL Cholesterol, LDL Cholesterol, Triglycerides, Creatinine, serum redox status indicators (GSH, GPx, GSTs, and MDA) and a complete blood count was performed.
Results
The findings of this study indicated a slight increase in arterial pressure in 336 diabetic patients (60%) with an HbA1c level between 7 and 9% (210 patients) and > 9% (126 patients); while the flow of the glomerular filtration remained within the norms for all the studied subjects. Patients showed an increase in blood glucose levels, disturbance of the lipid parameters with an increase in lipid peroxidation and a decrease in serum and erythrocyte antioxidant defense.