Macrophage-mediated inflammation has been implicated in the pathogenesis of metabolic dysfunction-associated steatohepatitis (MASH); however, the immunometabolic program underlying the regulation of macrophage activation remains unclear. Beta-arrestin 2, a multifunctional adaptor protein, is highly expressed in bone marrow tissues and macrophages and is involved in metabolism disorders. Here, we observed that β-arrestin 2 expression was significantly increased in the liver macrophages and circulating monocytes of patients with MASH compared with healthy controls and positively correlated with the severity of metabolic dysfunction-associated steatotic liver disease (MASLD). Global or myeloid Arrb2 deficiency prevented the development of MASH in mice. Further study showed that β-arrestin 2 acted as an adaptor protein and promoted ubiquitination of immune responsive gene 1 (IRG1) to prevent increased itaconate production in macrophages, which resulted in enhanced succinate dehydrogenase activity, thereby promoting the release of mitochondrial reactive oxygen species and M1 polarization. Myeloid β-arrestin 2 depletion may be a potential approach for MASH.
Myeloid beta-arrestin 2 depletion attenuates metabolic dysfunction-associated steatohepatitis via the metabolic reprogramming of macrophages.
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作者:Wei Xiaoli, Wu Dongqing, Li Jing, Wu Miaomiao, Li Qianhui, Che Zhaodi, Cheng Xu, Cheng Qianying, Yin Fan, Zhang Hao, Wang Xuefu, Abtahi Shabnam, Zuo Li, Hang Lei, Ma Lili, Kuo Wei-Ting, Liu Xiaoying, Turner Jerrold R, Wang Hua, Xiao Jia, Wang Fei
期刊: | Cell Metabolism | 影响因子: | 30.900 |
时间: | 2024 | 起止号: | 2024 Oct 1; 36(10):2281-2297 |
doi: | 10.1016/j.cmet.2024.08.010 |
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