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Irradiation-responsive PRDM10-DT modulates the angiogenic response in human NSCLC cells in an SP1-dependent manner via the miR-663a/TGF-β1 axis

放射反应性 PRDM10-DT 通过 miR-663a/TGF-β1 轴以 SP1 依赖的方式调节人类 NSCLC 细胞中的血管生成反应

影响因子:6.100

doi:10.1186/s12967-025-06273-0

Hao Huang #, Ying Xu #, Zi Guo, Miaomiao Zhang, Wanshi Li, Yidan Song, Jing Nie, Wentao Hu, Tom K Hei, Guangming Zhou

细胞生物学

发表日期：2025

Pharmacological Vitamin C-induced high H2O2 generation mediates apoptotic cell death by caspase 3/7 activation in breast cancer tumor spheroids

药理学维生素 C 诱导的高 H2O2 生成通过激活乳腺癌肿瘤球体中的 caspase 3/7 介导细胞凋亡

影响因子:6.100

doi:10.1186/s12967-024-06016-7

Ali Mussa, Mahasin Hamid, Khalid Hajissa, Ahmad Hafiz Murtadha, Mohammad A I Al-Hatamleh, Noor Fatmawati Mokhtar, Vuk Uskoković, Magdalena Plebanski, Rohimah Mohamud, Rosline Hassan4

发表日期：2025

Promoting the transition from pyroptosis to apoptosis in endothelial cells: a novel approach to alleviate methylglyoxal-induced vascular damage

促进内皮细胞从焦亡向凋亡的转变：一种缓解甲基乙二醛诱导的血管损伤的新方法

影响因子:6.100

doi:10.1186/s12967-025-06195-x

Ruqiang Yuan #, Hu Xu #, Mingqi Wang #, Lina Guo, Yang Yao, Xiaoru Zhang, Xiuli Wang

细胞生物学

发表日期：2025

LIN28A-dependent lncRNA NEAT1 aggravates sepsis-induced acute respiratory distress syndrome through destabilizing ACE2 mRNA by RNA methylation

LIN28A 依赖的 lncRNA NEAT1 通过 RNA 甲基化破坏 ACE2 mRNA 的稳定性，加重脓毒症引起的急性呼吸窘迫综合征

影响因子:6.100

doi:10.1186/s12967-024-06032-7

Jun Liu #, Xiang Li #, Peng Yang #, Yufeng He, Weilong Hong, Yawei Feng, Zhiqiang Ye

发表日期：2025

CRAT downregulation promotes ovarian cancer progression by facilitating mitochondrial metabolism through decreasing the acetylation of PGC-1α

CRAT 下调通过降低 PGC-1α 的乙酰化促进线粒体代谢，从而促进卵巢癌进展

影响因子:6.100

doi:10.1038/s41420-025-02294-2

Zhen Zhang #, Shuhua Zhao #, Xiaohui Lv #, Yan Gao, Qian Guo, Yanjie Ren, Yuanyuan He, Yihua Jin, Hong Yang, Shujuan Liu, Xiaohong Zhang

发表日期：2025

Long non-coding RNA MIR4435-2HG modulates pancreatic cancer stem cells and chemosensitivity to gemcitabine by targeting the miR-1252-5p/STAT1

长链非编码 RNA MIR4435-2HG 通过靶向 miR-1252-5p/STAT1 调节胰腺癌干细胞及其对吉西他滨的化学敏感性

影响因子:6.100

doi:10.1186/s12967-025-06128-8

Baocheng Xie #, Peishan Wu #, Hongyu Liu, XiangDi Yang, Linxuan Huang

发育与干细胞

发表日期：2025

Hypoxic BMSC-derived exosomal miR-210-3p promotes progression of triple-negative breast cancer cells via NFIX-Wnt/β-catenin signaling axis

缺氧 BMSC 衍生的外泌体 miR-210-3p 通过 NFIX-Wnt/β-catenin 信号轴促进三阴性乳腺癌细胞进展

影响因子:6.100

doi:10.1186/s12967-024-05947-5

Meng Wang, Yi Zheng, Qian Hao, Guochao Mao, Zhijun Dai, Zhen Zhai, Shuai Lin, Baobao Liang, Huafeng Kang, Xiaobin Ma

细胞生物学

发表日期：2025

Transcriptomic profiling identifies ferroptosis and NF-κB signaling involved in α-dimorphecolic acid regulation of microglial inflammation

转录组分析确定铁死亡和 NF-κB 信号参与 α-二吗啉甲酸调节小胶质细胞炎症

影响因子:6.100

doi:10.1186/s12967-025-06296-7

Xiao-Xi Zhu #, Pei-Juan Wang #, Shan Chao, Wei-Jia Tang, Long-You Zhao, Li-Mei Yu, Fan Yang

细胞生物学

发表日期：2025

Ginger protects against vein graft remodeling by precisely modulating ferroptotic stress in vascular smooth muscle cell dedifferentiation

姜通过精确调节血管平滑肌细胞去分化中的铁死亡应激来防止静脉移植重塑

影响因子:6.100

doi:10.1016/j.jpha.2024.101053

Xiaoyu Yu, Weiwei Wu, Jingjun Hao, Yuxin Zhou, Deyang Yu, Wei Ding, Xuejuan Zhang, Gaoli Liu, Jianxun Wang

细胞生物学

发表日期：2025

Insufficient expression of COL6A1 promotes the development of early-onset severe preeclampsia by inhibiting the APJ/AKT signaling pathway

COL6A1表达不足通过抑制APJ/AKT信号通路促进早发型重度子痫前期的发展

影响因子:6.100

doi:10.1038/s41420-025-02373-4

Gonghua Qi #, Yanmin Gong #, Yi Li, Yanhui Jin, Shuqi Chi, Wenxia Zhang, Xia Luo

发表日期：2025