共为您找到 5473 个结果

Genetic architecture and cross-platform validation of apolipoprotein A-IV concentrations

载脂蛋白A-IV浓度的遗传结构和跨平台验证

Adriana Koller, Florian Schnitzer, Barbara Kollerits, Claudia Lamina, Samuel Moix, Annique Claringbould, Binisha H Mishra, Haojie Lu, Johanna F Schachtl-Riess, Lukas Forer, Christian Gieger, Azin Kheirkhah, Terho Lehtimäki, Pedro Marques-Vidal, Sebastian Schönherr, Klaus J Stark, Reinhard Würzner, Kai-Uwe Eckardt, Iris M Heid, Maryam Kavousi, Anna Köttgen, Olli Raitakari, Eric J G Sijbrands, Annette Peters, Peter Vollenweider, Florian Kronenberg

Lentiviral single-cell MPRA of synthetic enhancers reveals motif affinity-based encoding of cell state specificity

利用慢病毒单细胞MPRA技术研究合成增强子,揭示了基于基序亲和力的细胞状态特异性编码机制

Julia Rühle, Robert Frömel, Aina Bernal Martinez, Chelsea Szu-Tu, Joseph Bowness, Lars Velten

Targeting lysosome-dependent cell death in cancer: towards therapeutic strategies

靶向溶酶体依赖性细胞死亡治疗癌症:迈向治疗策略

Yang Li, Jiajie Feng, Xinzhu Dong, Ziyue Yuan, Ling-Li Zheng, Lan Zhang, Lei Wang

TBL1XR1 mutations promoted tumor progression in diffuse large B-cell lymphoma through impairing nature killer cytotoxicity via the MYC-CD47/PD-L1 axis

TBL1XR1突变通过MYC-CD47/PD-L1轴抑制自然杀伤细胞的细胞毒性,从而促进弥漫性大B细胞淋巴瘤的肿瘤进展。

Yue Zhu, Yi-Ge Shen, Wei Tang, Zhong Zheng, Si-Yuan Chen, Yao-Hui Huang, Di Fu, Shu Cheng, Peng-Peng Xu, Li Wang, Jiahao Chen, Meng-Meng Ji, Wei-Li Zhao

L-NAME promotes foam cell formation and synthetic phenotype marker changes in vascular smooth muscle cells independent of hemodynamic effects

L-NAME促进血管平滑肌细胞泡沫细胞形成和合成表型标志物改变,且该作用独立于血流动力学效应。

Huanhua Du, Jia Ling, Zheng Lu, Yutong Liu, Jinsong Yan, Junli Ma, Li Li, Gang Chen

CIT-Lasso: a scalable approach beyond guilty by association for identifying causal variants from genome-wide summary statistics

CIT-Lasso:一种超越关联性推断的可扩展方法,用于从全基因组汇总统计数据中识别致病变异

Zihuai He, Benjamin Chu, James Yang, Jiaqi Gu, Zhaomeng Chen, Linxi Liu, Tim Morrison, Michael E Belloy, Xinran Qi, Nima Hejazi, Maya Mathur, Yann Le Guen, Hua Tang, Trevor Hastie, Iuliana Ionita-Laza, Emmanuel Candès, Chiara Sabatti

Long-read metagenomics and methylation-based binning support the discovery of antibiotic resistance gene-host associations in complex communities

长读长宏基因组学和基于甲基化的分箱方法有助于发现复杂群落中抗生素耐药基因与宿主之间的关联

Melina Markkanen, Heidi Putkuri, Dovydas Kičiatovas, Ville Mustonen, Marko Virta, Antti Karkman

Comparing machine learning methods predicting transcriptome from epigenome with applications to association studies

比较基于表观基因组预测转录组的机器学习方法及其在关联研究中的应用

Fatemeh Behjati Ardakani, Shamim Ashrafiyan, Laura Rumpf, Dennis Hecker, Marcel H Schulz

Evidence standards for multi-ancestry polygenic prediction

多祖源多基因预测的证据标准

Blessing Oselu, Itunuoluwa Isewon, Jelili Oyelade, Conrad O Iyegbe

Splice-altering TP53 missense mutations as drivers of dysfunction and targets for RNA-based therapy

TP53剪接改变性错义突变是功能障碍的驱动因素和基于RNA疗法的靶点

Sun-Ku Chung, Han-Byul Jung, Su-Jin Baek, Sang-Min Park, Jinchul Kim, Seo-Young Lee, Byungkuk Min, Yong-Kook Kang