Acute iron overload leads to ferroptosis, in a mouse model of FeSO(4) challenge causing lethal shock, associated with inflammation and multiple organ failure (MOF). We investigated molecular aspects causing this phenomenon upon FeSO(4) overload, with a focus on the glucocorticoid receptor (GR), an important anti-inflammatory transcription factor. We report that Fe overload activates the HPA axis, leading to corticosterone increases in the blood, acutely causing upregulation of GR-dependent genes in liver. Using a GR blocker, mice with a reduced GR dimerization potential and removal of adrenal glands sensitizes mice for Fe-induced toxicity, GR appears essential to resist ferroptosis. However, stimulating GR with DEX is unable to protect mice against FeSO(4)-induced MOF and death. This dilemma is shown, by RNA sequencing, to be the result of a quick and complete inactivation of GR biological function by Fe(2+), shortly after the initial activation. This inactivity of GR seems to be the result of a complete lack of GR to bind its ligand. We discuss the possible mechanism and complications for ferroptosis progression during diseases.
Modulation of glucocorticoid receptor function under iron overload.
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作者:Zhu Wanting, Vanderhaeghen Tineke, Timmermans Steven, Vandewalle Jolien, Eggermont Melanie, Verhoog Nicolette J D, Libert Claude
期刊: | Frontiers in Immunology | 影响因子: | 5.900 |
时间: | 2025 | 起止号: | 2025 Jun 18; 16:1605420 |
doi: | 10.3389/fimmu.2025.1605420 |
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