MedComm

Osteoarthritis synovium as a nidus for monosodium urate crystal deposition inducing severe gout studied by label-free stimulated Raman scattering combined with synovial organoids.

Eupalinolide B inhibits periodontitis development by targeting ubiquitin conjugating enzyme UBE2D3.

Eupalinolide B 通过靶向泛素结合酶 UBE2D3 来抑制牙周炎的发展

Tripartite Motif Containing 65 Deficiency Confers Protection Against Acute Kidney Injury via Alleviating Voltage-Dependent Anion Channel 1-Mediated Mitochondrial Dysfunction.

含有 65 的三方基序缺陷通过减轻电压依赖性阴离子通道 1 介导的线粒体功能障碍来提供对急性肾损伤的保护

T Cell-Specific Deficiency of Src Homology 2-Containing Protein Tyrosine Phosphatase 2 Ameliorates Psoriasis and Colitis by Promoting Treg Differentiation.

T 细胞特异性缺乏 Src 同源性 2 蛋白酪氨酸磷酸酶 2 可通过促进 Treg 分化来改善银屑病和结肠炎

Heat Shock Protein Family A Member 1A Attenuates Apoptosis and Oxidative Stress via ERK/JNK Pathway in Hyperplastic Prostate.

热休克蛋白家族 A 成员 1A 通过 ERK/JNK 通路减弱增生性前列腺中的细胞凋亡和氧化应激

Hypomethylation-Triggered SERPINE1 (Serpin Family E Member 1) Exacerbates Polycystic Ovary Syndrome with Hyperandrogenism Induced by Circadian Disruption.

低甲基化触发的 SERPINE1（丝氨酸蛋白酶抑制剂家族 E 成员 1）加剧了由昼夜节律紊乱引起的伴有高雄激素血症的多囊卵巢综合征

Sulfide Quinone Oxidoreductase Alleviates Acute Ulcerative Colitis by Regulating Mitochondrial Dysfunction.

硫化物醌氧化还原酶通过调节线粒体功能障碍缓解急性溃疡性结肠炎

Novel Trispecific Neutralizing Antibodies With Enhanced Potency and Breadth Against Pan-Sarbecoviruses.

新型三特异性中和抗体，对泛沙贝病毒具有增强的效力和广谱性

Crizotinib: A Novel Strategy to Reverse Immunosuppression in Melanoma by Targeting Lactate Transport.

克唑替尼：一种通过靶向乳酸转运逆转黑色素瘤免疫抑制的新策略

Gene Therapy Targeting Pkp2 Deficiency Attenuates Cardiac Fibrosis: Insights From Single-Cell Transcriptomics in Pkp2-Knockout Rats.

针对 Pkp2 缺陷的基因治疗可减轻心脏纤维化：来自 Pkp2 敲除大鼠单细胞转录组学的见解