Bioorganic & Medicinal Chemistry

Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin

基于结构的设计和优化一类针对蓖麻毒素 P 柄结合位点的新型小分子抑制剂

Structural resemblances and comparisons of the relative pharmacological properties of imatinib and nilotinib

伊马替尼和尼洛替尼的结构相似性和相对药理特性的比较

Discovery of small molecule benzothiazole and indole derivatives tackling tau 2N4R and α-synuclein fibrils

发现针对 tau 2N4R 和 α-突触核蛋白原纤维的小分子苯并噻唑和吲哚衍生物

1,2,3-Triazole-totarol conjugates as potent PIP5K1α lipid kinase inhibitors

1,2,3-三唑-桃金娘酚结合物作为有效的 PIP5K1α 脂质激酶抑制剂

SuFEx-based chemical diversification for the systematic discovery of CRBN molecular glues

基于 SuFEx 的化学多样化，系统地发现 CRBN 分子胶

Design, synthesis and anti-necroptosis activity of fused heterocyclic MLKL inhibitors

稠杂环MLKL抑制剂的设计、合成及抗坏死凋亡活性

Discovery of novel biaryl benzoxazepinones as dual-mode receptor-interacting protein kinase-1 (RIPK1) inhibitors

发现新型双芳基苯并氧氮杂卓酮作为双模式受体相互作用蛋白激酶 1 (RIPK1) 抑制剂

Development of a tetrahydroindazolone-based HDAC6 inhibitor with in-vivo anti-arthritic activity

开发具有体内抗关节炎活性的四氢吲哚基 HDAC6 抑制剂

RNA sequences that direct selective ADAR editing from a SELEX library bearing 8-azanebularine.

Synthesis and biological evaluation of tert-butyl ester and ethyl ester prodrugs of L-γ-methyleneglutamic acid amides for cancer

L-γ-亚甲基谷氨酸酰胺叔丁酯和乙酯前药的合成及抗癌活性评价