Journal of Enzyme Inhibition and Medicinal Chemistry

Identification of a novel pyrrolo[2,3- b]pyridine compound as a potent glycogen synthase kinase 3β inhibitor for treating Alzheimer's disease

鉴定出一种新型吡咯并[2,3-b]吡啶化合物，作为治疗阿尔茨海默病的有效糖原合酶激酶 3β 抑制剂

Development of ketobenzothiazole-based peptidomimetic TMPRSS13 inhibitors with low nanomolar potency

开发低纳摩尔效力的酮苯并噻唑类肽模拟物 TMPRSS13 抑制剂

Natural product as a lead for impairing mitochondrial respiration in cancer cells

天然产物作为损害癌细胞线粒体呼吸的先导

Rational design, synthesis, and molecular modelling insights of dual DNA binders/DHFR inhibitors bearing arylidene-hydrazinyl-1,3-thiazole scaffold with apoptotic and anti-migratory potential in breast MCF-7 cancer cells.

Inhibition of 12/15-LOX hyperactivation mitigates cognitive decline in a chronic cerebral hypoperfusion mouse model and in H(2)O(2)-induced HT22 cells: therapeutic effects of brozopine.

A multidisciplinary approach to the antioxidant and hepatoprotective activities of Arbutus pavarii Pampan fruit; in vitro and in Vivo biological evaluations, and in silico investigations

采用多学科方法研究 Arbutus pavarii Pampan 果实的抗氧化和保肝活性；体外和体内生物学评价以及计算机模拟研究

Ligand-based pharmacophore modelling, structure optimisation, and biological evaluation for the identification of 2-heteroarylthio- N-arylacetamides as novel HSP90 C-terminal inhibitors

基于配体的药效团建模、结构优化和生物学评价，用于鉴定 2-杂芳硫基-N-芳基乙酰胺作为新型 HSP90 C 端抑制剂

Imparting aromaticity to 2-pyridone derivatives by O-alkylation resulted in new competitive and non-competitive PIM-1 kinase inhibitors with caspase-activated apoptosis

通过 O-烷基化赋予 2-吡啶酮衍生物芳香性，产生具有 caspase 激活细胞凋亡作用的新型竞争性和非竞争性 PIM-1 激酶抑制剂

Structure optimization and molecular dynamics studies of new tumor-selective s-triazines targeting DNA and MMP-10/13 for halting colorectal and secondary liver cancers

针对 DNA 和 MMP-10/13 的新型肿瘤选择性 s-三嗪的结构优化和分子动力学研究，用于阻止结直肠癌和继发性肝癌

Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation

发现一种新型双特异性酪氨酸磷酸化调节激酶 1A (DYRK1A) 抑制剂及其对 tau 磷酸化和淀粉样蛋白 β 形成的影响