Molecular Pharmacology

High-throughput screening identifies a novel small-molecule modulator of Hsp70 that selectively enhances ubiquitination and degradation of misfolded neuronal NO synthase.

β-Caryophyllene Inhibits Monoacylglycerol Lipase Activity and Increases 2-Arachidonoyl Glycerol Levels In Vivo: A New Mechanism of Endocannabinoid-Mediated Analgesia?

β-石竹烯抑制单酰甘油脂肪酶活性并增加体内2-花生四烯酰甘油水平：内源性大麻素介导镇痛的新机制？

Identification of NanoLuciferase Substrates Transported by Human ABCB1 and ABCG2 and Their Zebrafish Homologs at the Blood-Brain Barrier

鉴定人类 ABCB1 和 ABCG2 及其斑马鱼同源物在血脑屏障处运输的纳米荧光素酶底物

Drugs Form Ternary Complexes with Human Liver Fatty Acid Binding Protein 1 (FABP1) and FABP1 Binding Alters Drug Metabolism

药物与人肝脂肪酸结合蛋白 1 (FABP1) 形成三元复合物，FABP1 结合改变药物代谢

The M3 Muscarinic Acetylcholine Receptor Can Signal through Multiple G Protein Families

M3 毒蕈碱乙酰胆碱受体可通过多个 G 蛋白家族发出信号

A Constitutive EGFR Kinase Dimer to Study Inhibitor Pharmacology

组成型 EGFR 激酶二聚体用于研究抑制剂药理学

Intracellular Allosteric Antagonist of the Olfactory Receptor OR51E2

嗅觉受体 OR51E2 的细胞内变构拮抗剂

Extrahelical Binding Site for a 1 H-Imidazo[4,5-c]quinolin-4-amine A3 Adenosine Receptor Positive Allosteric Modulator on Helix 8 and Distal Portions of Transmembrane Domains 1 and 7

H-咪唑并[4,5-c]喹啉-4-胺 A3 腺苷受体正变构调节剂在螺旋 8 和跨膜域 1 和 7 的远端部分的螺旋外结合位点

BAY58-2667 Activates Different Soluble Guanylyl Cyclase Species by Distinct Mechanisms that Indicate Its Principal Target in Cells is the Heme-Free Soluble Guanylyl Cyclase-Heat Shock Protein 90 Complex

BAY58-2667 通过不同的机制激活不同的可溶性鸟苷酸环化酶种类，表明其在细胞中的主要靶标是无血红素的可溶性鸟苷酸环化酶-热休克蛋白 90 复合物

Insights Into the Differential Desensitization of α 4 β 2 Nicotinic Acetylcholine Receptor Isoforms Obtained With Positive Allosteric Modulation of Mutant Receptors

通过突变受体的正向变构调节获得对 α 4 β 2 烟碱型乙酰胆碱受体异构体的差异脱敏的洞察