Molecular Neurodegeneration

Mutations in NEK1 cause ciliary dysfunction as a novel pathogenic mechanism in amyotrophic lateral sclerosis.

Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques.

β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity.

Srebf2 mediates successful optic nerve axon regeneration via the mevalonate synthesis pathway.

LRRK2 kinase activity regulates Parkinson's disease-relevant lipids at the lysosome.

Methylome analysis of FTLD patients with TDP-43 pathology identifies epigenetic signatures specific to pathological subtypes.

Alzheimer's disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication.

Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology.

The transcription factor combination MEF2 and KLF7 promotes axonal sprouting in the injured spinal cord with functional improvement and regeneration-associated gene expression

转录因子组合 MEF2 和 KLF7 促进受损脊髓轴突发芽，改善功能并促进再生相关基因表达

Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis

上调星形胶质细胞 HDAC7 通过去乙酰化转录因子-EB 和抑制溶酶体生物合成诱导阿尔茨海默病样 tau 病理