Cancer Research

Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models.

Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors.

Mutation of SMARCA4 Induces Cancer Cell-Intrinsic Defects in the Enhancer Landscape and Resistance to Immunotherapy.

SMARCA4 突变导致癌细胞增强子景观的内在缺陷和对免疫疗法的耐药性

Interactions between Ploidy and Resource Availability Shape Clonal Evolution in Glioblastoma.

倍性与资源可用性之间的相互作用塑造了胶质母细胞瘤的克隆演化

AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer.

AREG 和 EREG 是胃食管癌中 EGFR 抑制剂疗效的预测生物标志物

A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer.

一种具有独特作用机制的泛 RAS 抑制剂可抑制肿瘤生长并诱导胃肠道癌症的抗肿瘤免疫

CXCL10 Secreted by Pericytes Mediates TNFα-Induced Vascular Leakage in Tumors and Enhances Extravasation of Nanoparticle-Based Chemotherapeutics.

周细胞分泌的 CXCL10 介导 TNFα 诱导的肿瘤血管渗漏，并增强纳米颗粒化疗药物的外渗

PPARδ Orchestrates a Prometastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer.

PPARδ 在胰腺癌中协调对微环境信号的促转移代谢反应

Combining Spatial Transcriptomics, Pseudotime, and Machine Learning Enables Discovery of Biomarkers for Prostate Cancer.

结合空间转录组学、伪时间和机器学习技术，可以发现前列腺癌的生物标志物

Oxytocin Receptor Regulates the Hippo/YAP Axis to Drive Hepatocarcinogenesis.

催产素受体调节 Hippo/YAP 轴以驱动肝癌发生