Chemistry & Biology

Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases.

Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides.

The Structure and Interactions of Periplasmic Domains of Crucial MmpL Membrane Proteins from Mycobacterium tuberculosis.

Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species.

分子网络和基于模式的基因组挖掘提高了对盐生孢子菌属物种生物合成基因簇及其产物的发现

The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes.

四环素破坏酶：一类新型的四环素灭活酶

Engineering Duplex RNAs for Challenging Targets: Recognition of GGGGCC/CCCCGG Repeats at the ALS/FTD C9orf72 Locus.

针对具有挑战性的目标设计双链 RNA：识别 ALS/FTD C9orf72 位点的 GGGGCC/CCCCGG 重复序列

The Effect of Detergent, Temperature, and Lipid on the Oligomeric State of MscL Constructs: Insights from Mass Spectrometry.

洗涤剂、温度和脂质对 MscL 构建体寡聚状态的影响：来自质谱的见解

D-enantiomeric peptides that eradicate wild-type and multidrug-resistant biofilms and protect against lethal Pseudomonas aeruginosa infections.

D-对映体肽可根除野生型和多重耐药生物膜，并防止致命的铜绿假单胞菌感染

High-Throughput Multiplexed Peptide-Centric Profiling Illustrates Both Substrate Cleavage Redundancy and Specificity in the MMP Family.

高通量多重肽中心分析揭示了 MMP 家族的底物切割冗余性和特异性

XBP1s Links the Unfolded Protein Response to the Molecular Architecture of Mature N-Glycans.

XBP1s 将未折叠蛋白反应与成熟 N-糖的分子结构联系起来