Chemistry & Biology

Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics.

Global analysis of protein N-myristoylation and exploration of N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani

蛋白质 N-肉豆蔻酰化的整体分析和 N-肉豆蔻酰转移酶作为被忽视的人类病原体杜氏利什曼原虫的药物靶点的探索

Distinct Substrate Specificity and Catalytic Activity of the Pseudoglycosyltransferase VldE

假糖基转移酶VldE的独特底物特异性和催化活性

Islet amyloid-induced cell death and bilayer integrity loss share a molecular origin targetable with oligopyridylamide-based α-helical mimetics

胰岛淀粉样蛋白诱导的细胞死亡和双层完整性丧失具有共同的分子起源，可通过寡吡啶酰胺基 α-螺旋模拟物进行靶向治疗

An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in α7 Nicotinic Acetylcholine Receptors

PNU-120596 在 α7 烟碱乙酰胆碱受体中的未改变的正构位点和长距离变构相互作用网络

Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks

位点特异性蛋白质组学图谱识别功能不同的蛋白质网络中选择性修饰的调节性半胱氨酸残基

Dual and Opposite Effects of hRAD51 Chemical Modulation on HIV-1 Integration

hRAD51 化学调节对 HIV-1 整合的双重和相反影响

Identification and Characterization of an Irreversible Inhibitor of CDK2

CDK2 不可逆抑制剂的鉴定和表征

Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis

基于靶标的结核分枝杆菌全细胞生物素生物合成活性抑制剂鉴定

Bioengineering and semisynthesis of an optimized cyclophilin inhibitor for treatment of chronic viral infection

优化环丝氨酸蛋白酶抑制剂的生物工程和半合成用于治疗慢性病毒感染