Medicinal Chemistry Research

Design, synthesis, and biological evaluation of new 2-(4-(methylsulfonyl)phenyl)- N-phenylimidazo[1,2- a]pyridin-3-amine as selective COX-2 inhibitors

新型 2-(4-(甲基磺酰基)苯基)-N-苯基咪唑并[1,2-a]吡啶-3-胺作为选择性 COX-2 抑制剂的设计、合成及生物学评价

Evaluation of a series of nucleoside analogs as effective anticoronaviral-2 drugs against the Omicron-B.1.1.529/BA.2 subvariant: A repurposing research study

评估一系列核苷类似物作为针对 Omicron-B.1.1.529/BA.2 亚变体的有效抗冠状病毒 2 药物：一项再利用研究

Development of convenient crystallization inhibition assays for structure-activity relationship studies in the discovery of crystallization inhibitors

开发便捷的结晶抑制检测方法，用于研究结晶抑制剂发现中的构效关系

Combination with a FtsZ inhibitor potentiates the in vivo efficacy of oxacillin against methicillin-resistant Staphylococcus aureus.

Synthesis and antitumor activity of novel silibinin and 2,3-dehydrosilybin derivatives with carbamate groups.

Design, synthesis and evaluation of amino-3,5-dicyanopyridines and thieno[2,3-b]pyridines as ligands of adenosine A1 receptors for the potential treatment of epilepsy

氨基-3,5-二氰基吡啶和噻吩并[2,3-b]吡啶的设计、合成及作为腺苷 A1 受体配体治疗癫痫的潜力评估

Design and discovery of a high affinity, selective and β-arrestin biased 5-HT7 Receptor Agonist

设计和发现高亲和力、选择性和 β-arrestin 偏向的 5-HT7 受体激动剂

Design, synthesis, and LFA-1/ICAM-1 antagonist activity evaluation of Lifitegrast analogues

Lifitegrast 类似物的设计、合成及 LFA-1/ICAM-1 拮抗剂活性评估

Synthesis of 2-Oxoquinoline Derivatives as Dual Pim and mTORC Protein Kinase Inhibitors

2-氧喹啉衍生物作为 Pim 和 mTORC 蛋白激酶双重抑制剂的合成

Innovation in the discovery of the HIV-1 attachment inhibitor temsavir and its phosphonooxymethyl prodrug fostemsavir.