Deletion of the Lmna gene in fibroblasts causes senescence-associated dilated cardiomyopathy by activating the double-stranded DNA damage response and induction of senescence-associated secretory phenotype
成纤维细胞中 Lmna 基因的缺失会激活双链 DNA 损伤反应并诱导衰老相关的分泌表型,从而导致衰老相关的扩张型心肌病
期刊:Journal of Cardiovascular Aging
影响因子:12.800
doi:10.20517/jca.2022.14
Leila Rouhi, Gaelle Auguste, Qiong Zhou, Raffaella Lombardi, Melis Olcum, Kimia Pourebrahim, Sirisha M Cheedipudi, Saman Asghar, Kui Hong, Matthew J Robertson, Cristian Coarfa, Priyatansh Gurha, Ali J Marian
信号转导
心血管
心肌病
成纤维细胞
Senescence