Molecular Therapy Oncology

Preclinical development and clinical safety assessment of a synthetic peptide conjugate enabling endogenous antibody binding to promote innate receptor engagement.

Insights into expression and localization of HPV16 LCR-associated transcription factors and association with LCR activity in HNSCC.

DNA-demethylation by DAC induces MAGE expression and MAGE-specific T cell reactivity against tumors but also healthy cell subsets.

The oligosaccharyltransferase complex is an essential component of multiple myeloma plasma cells.

Perturbed CD81 in lung-cancer-derived extracellular vesicles modifies its function in cancer pathophysiology.

肺癌细胞外囊泡中 CD81 的异常改变会改变其在癌症病理生理学中的功能

Preclinical study of microphthalmia-associated transcription factor inhibitor ML329 in gastrointestinal stromal tumor growth.

小眼畸形相关转录因子抑制剂 ML329 在胃肠道间质瘤生长中的临床前研究

hsa-miR-5688 inhibits FOXC1-OCT4/SOX2 feedforward loop that drives chemoresistance in breast cancer stem cells.

hsa-miR-5688 抑制 FOXC1-OCT4/SOX2 前馈环路，从而抑制乳腺癌干细胞的化疗耐药性

Development of multivalent CAR T cells as dual immunotherapy and conditioning agents.

开发多价 CAR T 细胞作为双重免疫疗法和预处理剂

circ-1584 selectively promotes the antitumor activity of the oncolytic virus M1 on pancreatic cancer.

circ-1584 选择性地促进溶瘤病毒 M1 对胰腺癌的抗肿瘤活性

Targeted expansion of cytotoxic T cells using IL-12 and CD137L supplementation enhances antitumor efficacy.

利用IL-12和CD137L补充剂靶向扩增细胞毒性T细胞可增强抗肿瘤疗效