Nature Genetics

In vivo CRISPR-Cas9 genome editing in mice identifies genetic modifiers of somatic CAG repeat instability in Huntington's disease

小鼠体内 CRISPR-Cas9 基因组编辑可识别亨廷顿氏病中体细胞 CAG 重复不稳定性基因修饰因子

Human subcutaneous and visceral adipocyte atlases uncover classical and nonclassical adipocytes and depot-specific patterns

人类皮下和内脏脂肪细胞图谱揭示了经典和非经典脂肪细胞以及脂肪库特异性模式

Loss of Kmt2c or Kmt2d primes urothelium for tumorigenesis and redistributes KMT2A-menin to bivalent promoters

Kmt2c 或 Kmt2d 的缺失为尿路上皮的肿瘤发生提供了基础，并将 KMT2A-menin 重新分配到二价启动子上

Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer

癌胚重编程驱动 WNT 依赖性结直肠癌的表型可塑性

Precise modulation of BRG1 levels reveals features of mSWI/SNF dosage sensitivity.

Near-complete Middle Eastern genomes refine autozygosity and enhance disease-causing and population-specific variant discovery.

Cell state-dependent allelic effects and contextual Mendelian randomization analysis for human brain phenotypes.

Characterizing the evolutionary dynamics of cancer proliferation in single-cell clones with SPRINTER.

Analysis of individual patient pathway coordination in a cross-species single-cell kidney atlas.

A multilineage screen identifies actionable synthetic lethal interactions in human cancers.