Nature Genetics

期刊全称

Nature Genetics

期刊缩写

Nat. Genet.

涉及主题

生物遗传学化学生物化学基因医学内科学计算生物学进化生物学细胞生物学病理

期刊介绍

Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution -Nature Genetics

Nature Genetics

JCR学科分类

JCI学科分类

期刊相关文献 (917)

Near-complete Middle Eastern genomes refine autozygosity and enhance disease-causing and population-specific variant discovery

近乎完整的中东基因组有助于更精确地确定纯合性，并增强致病变异和人群特异性变异的发现。

Cell state-dependent allelic effects and contextual Mendelian randomization analysis for human brain phenotypes

细胞状态依赖性等位基因效应和人脑表型的背景孟德尔随机化分析

Massively parallel immunopeptidome by DNA sequencing provides insights into cancer antigen presentation

利用DNA测序进行大规模并行免疫肽组学分析，可深入了解癌症抗原呈递机制。

ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L

ERG驱动的前列腺癌起始依赖于细胞环境，并且需要KMT2A和DOT1L。

Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A

染色体碎裂相关21号染色体扩增通过DYRK1A的靶向过表达调控MPN向急变期转化

Predicting resistance to chemotherapy using chromosomal instability signatures

利用染色体不稳定性特征预测化疗耐药性

Longitudinal single-cell multiomic atlas of high-risk neuroblastoma reveals chemotherapy-induced tumor microenvironment rewiring

高危神经母细胞瘤的纵向单细胞多组学图谱揭示了化疗诱导的肿瘤微环境重塑

Phylogenetic inference reveals clonal heterogeneity in circulating tumor cell clusters

系统发育推断揭示循环肿瘤细胞簇的克隆异质性

Cytidine diphosphate diacylglycerol synthase 2 is a synthetic lethal target in mesenchymal-like cancers

胞苷二磷酸二酰甘油合酶2是间质样癌症中的合成致死靶点

In vivo CRISPR-Cas9 genome editing in mice identifies genetic modifiers of somatic CAG repeat instability in Huntington's disease

小鼠体内 CRISPR-Cas9 基因组编辑可识别亨廷顿氏病中体细胞 CAG 重复不稳定性基因修饰因子