Science Translational Medicine

Orthopedia regulates melanocortin 4 receptor transcription and energy homeostasis

骨科调节黑皮质素 4 受体转录和能量稳态

Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread.

G6PC2 controls glucagon secretion by defining the set point for glucose in pancreatic α cells.

Gene therapy ameliorates bowel dysmotility and enteric neuron degeneration and extends survival in lysosomal storage disorder mouse models.

Preclinical development of anti-CD21 chimeric antigen receptor T cells to treat T cell acute lymphoblastic leukemia.

抗CD21嵌合抗原受体T细胞治疗T细胞急性淋巴细胞白血病的临床前开发

Protective envelope dimer epitope-like antibodies are elicited against dengue virus in children after infection and vaccination.

儿童感染和接种疫苗后，体内会产生针对登革病毒的保护性包膜二聚体表位样抗体

Cardiac allograft tolerance can be achieved in nonhuman primates by donor bone marrow and kidney cotransplantation.

在非人灵长类动物中，通过供体骨髓和肾脏共同移植可以实现心脏同种异体移植耐受性

Proviruses in CD4(+) T cells reactive to autologous antigens contribute to nonsuppressible HIV-1 viremia.

对自身抗原有反应的 CD4(+) T 细胞中的前病毒会导致无法抑制的 HIV-1 病毒血症

Systemic administration of an RNA binding and cell-penetrating antibody targets therapeutic RNA to multiple mouse models of cancer.

系统性地施用一种 RNA 结合和细胞穿透抗体，将治疗性 RNA 靶向应用于多种小鼠癌症模型

Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models.

用 mRNA 编码的膜结合 HIV 包膜三聚体进行疫苗接种，可在动物模型中诱导中和抗体