Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by Cryptococcus neoformans.

永生化人脑内皮细胞系 HCMEC/D3 作为血脑屏障模型,有助于对新型隐球菌感染中枢神经系统进行体外研究

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作者:Vu Kiem, Weksler Babette, Romero Ignacio, Couraud Pierre-Olivier, Gelli Angie
Cryptococcus neoformans cells must cross the blood-brain barrier prior to invading the central nervous system. Here we demonstrate that the immortalized human brain endothelial cell line HCMEC/D3 is a useful alternative to primary brain endothelial cells as a model of the blood-brain barrier for studies of central nervous system infection.

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