Nutraceutical supplement slim reshaped colon histomorphology and reduces Mucispirillum schaedleri in obese mice.

INTRODUCTION: Bioactive compounds and whole foods have emerged as promising interventions to address gut microbiota dysbiosis linked to obesity. Compounds such as berberine and coenzyme Q10 are well-recognized for their roles in managing metabolic syndrome and exerting antioxidant effects, while beet pulp, rich in fiber and antioxidants, enhances gut health through additional prebiotic benefits. METHODS: This study evaluated the effects of a nutraceutical supplement, Slim, on the modulation of gut microbiota in obese mice induced by a high-fat diet. RESULTS: Our results demonstrated that Slim supplementation significantly improved lipid metabolism, reshaped colon histomorphology, and decreased levels of Mucispirillum schaedleri, which were correlated with VLDL-c and triglycerides. DISCUSSION: We suggest these effects are driven by a duplibiotic effect, resulting from the synergistic action of the bioactive compounds.