TMB is associated with the prognosis of egfr-mutated non-small cell lung cancer in Xuanwei, China.

AIMS: Study on the prognostic characteristics and biomarkers of lung cancer in Xuanwei Patients. MATERIALS AND METHODS: A retrospective analysis was conducted on the genetic data of 261 NSCLC patients, as well as the prognostic data of 133 patients. The relationship between prognosis and EGFR mutations in the Xuanwei and non Xuanwei cohorts was compared and analyzed. RESULTS: The superior progression-free survival (PFS) in Xuanwei patients was primarily observed in those with EGFR-mutated tumors (p < 0.05). Further analysis of accompanying mutations and TMB levels revealed an association between high TMB and a favorable prognosis in EGFR-mutated Xuanwei NSCLC. CONCLUSION: Xuanwei lung cancer differs from non Xuanwei patients in terms of prognosis and tumor mutation burden, and further research should be conducted.