PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway.

PIN1脯氨酰异构酶通过SREBP2介导的胆固醇生物合成途径促进膀胱癌的发生和发展

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作者:Wang Xue, Lee Derrick, Xu Haibo, Sui Yuan, Meisenhelder Jill, Hunter Tony
This study provides deeper insights into the regulatory role of the phospho-dependent prolyl isomerase PIN1 in bladder cancer. The identification of the link between PIN1 and SREBP2-mediated transcription and cholesterol biosynthesis offers the potential for developing novel therapeutic strategies for bladder cancer.

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