Relationship Between LTA4H Promotor Polymorphism and Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome and Its Prevention With Prednisone.

LTA4H启动子多态性与结核病相关免疫重建炎症综合征的关系及其用泼尼松预防

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作者:Stek Cari, Shey Muki, Mnika Khuthala, Schutz Charlotte, Thienemann Friedrich, Wilkinson Robert J, Lynen Lutgarde, Meintjes Graeme
The development of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) and its prevention using prednisone may potentially be mediated by the LTA4H genotype. We assessed this hypothesis in a clinical trial evaluating prednisone to prevent TB-IRIS. We did not find an association between LTA4H genotype and TB-IRIS incidence or prednisone efficacy.

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