The development of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) and its prevention using prednisone may potentially be mediated by the LTA4H genotype. We assessed this hypothesis in a clinical trial evaluating prednisone to prevent TB-IRIS. We did not find an association between LTA4H genotype and TB-IRIS incidence or prednisone efficacy.
Relationship Between LTA4H Promotor Polymorphism and Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome and Its Prevention With Prednisone.
LTA4H启动子多态性与结核病相关免疫重建炎症综合征的关系及其用泼尼松预防
阅读:6
作者:Stek Cari, Shey Muki, Mnika Khuthala, Schutz Charlotte, Thienemann Friedrich, Wilkinson Robert J, Lynen Lutgarde, Meintjes Graeme
| 期刊: | Open Forum Infectious Diseases | 影响因子: | 3.800 |
| 时间: | 2023 | 起止号: | 2023 Jul 17; 10(7):ofad379 |
| doi: | 10.1093/ofid/ofad379 | 研究方向: | 炎症/感染 |
特别声明
1、本页面内容包含部分的内容是基于公开信息的合理引用;引用内容仅为补充信息,不代表本站立场。
2、若认为本页面引用内容涉及侵权,请及时与本站联系,我们将第一时间处理。
3、其他媒体/个人如需使用本页面原创内容,需注明“来源:[生知库]”并获得授权;使用引用内容的,需自行联系原作者获得许可。
4、投稿及合作请联系:info@biocloudy.com。
