Effect of exogenous interleukin-18 (IL-18) and IL-12 in the course of Brucella abortus 2308 infection in mice.

外源性白细胞介素-18 (IL-18) 和 IL-12 对小鼠布鲁氏菌 2308 感染过程的影响

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作者:Pasquali Paolo, Adone Rosanna, Gasbarre Louis C, Pistoia Claudia, Ciuchini Franco
In this study we demonstrated that combined inoculation of interleukin-12 (IL-12) and IL-18 reduced the number of bacteria in the spleens of mice infected with Brucella abortus 2308 and that the effect of the treatment was mediated by an increased capability of spleen cells to produce gamma interferon at the early phase of infection.

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