BACKGROUND: Underlying immunological mechanisms in children with moderate-to-severe asthma are complex and unclear. We aimed to investigate the association between blood inflammatory parameters and asthma burden in children with moderate-to-severe asthma. METHODS: Blood inflammatory parameters (eosinophil and neutrophil counts and inflammatory mediators using multiplex immunoassay technology) were measured in children (6-17â years) with moderate-to-severe asthma from the SysPharmPediA cohort across four European countries. Based upon low/high blood eosinophil (LBE/HBE) counts of
Association of blood inflammatory phenotypes and asthma burden in children with moderate-to-severe asthma.
中重度哮喘儿童血液炎症表型与哮喘负担的相关性
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作者：Alizadeh Bahmani Amir Hossein, Vijverberg Susanne J H, Hashimoto Simone, Wolff Christine, Almqvist Catarina, Bloemsma Lizan D, Brandstetter Susanne, Corcuera-Elosegui Paula, Gorenjak Mario, Harner Susanne, Hedman Anna M, Kabesch Michael, López-Fernández Leyre, Kraneveld Aletta D, Neerincx Anne H, Pino-Yanes Maria, PotoÄnik UroÅ¡, Sardón-Prado Olaia, Dierdorp Barbara S, Dekker Tamara, Metwally Nariman K A, Duitman Jan Willem, Lutter René, Brinkman Paul, Abdel-Aziz Mahmoud I, Maitland-van der Zee Anke H
| 期刊： | Erj Open Research | 影响因子： | 4.000 |
| 时间： | 2024 | 起止号： | 2024 Dec 16; 10(6):00222-2024 |
| doi： | 10.1183/23120541.00222-2024 | 研究方向： | 免疫/内分泌 |
| 疾病类型： | 哮喘 | ||
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