Intracellular recordings were made from isolated circular muscle bundles of rat gastric fundus. The majority of cells generated an ongoing discharge of electrical activity that were 15 min) resulted in the spread of dye between CSMC, between ICC-IM, and between CSMC and ICC-IM. Two types of STDs were observed, regularly occurring continuous STDs and irregular noisy bursting STDs. The amplitude of STDs varied between the two types of STDs. Single units summed to develop STDs with a maximum amplitude of 30 mV. Sodium nitroprusside (3 microM) induced membrane hyperpolarization and abolished unitary potentials generated by CSMC. In contrast, the amplitude of STDs generated by ICC-IM was increased with membrane hyperpolarization. Hyperpolarization induced by pinacidil (10 microM) also increased the amplitude of STDs and enhanced dV/dt(max). These observations indicate that STDs generated in ICC-IM spread passively to the adjacent CSMC to evoke the discharge of unitary potentials in the gastric fundus.
Interstitial cells of Cajal generate spontaneous transient depolarizations in the rat gastric fundus.
大鼠胃底的卡哈尔间质细胞可产生自发性瞬时去极化
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作者：Kito Yoshihiko, Sanders Kenton M, Ward Sean M, Suzuki Hikaru
| 期刊： | American Journal of Physiology-Gastrointestinal and Liver Physiology | 影响因子： | 3.300 |
| 时间： | 2009 | 起止号： | 2009 Oct;297(4):G814-24 |
| doi： | 10.1152/ajpgi.00118.2009 | 种属： | Rat |
| 研究方向： | 细胞生物学 | ||
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