SOCS1 Protects Acute Myeloid Leukemia against Allogeneic T Cell-Mediated Cytotoxicity.

SOCS1 可保护急性髓系白血病免受同种异体 T 细胞介导的细胞毒性作用

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作者:Tin Enoch, Rutella Sergio, Khatri Ismat, Na Yoosu, Yan Yongran, MacLean Neil, Vadakekolathu Jayakumar, Minden Mark D, Schimmer Aaron D, Lee JongBok, Zhang Li
Our investigation of the SOCS1 pathway in AML and T-cell interactions provides insights into potential mechanisms of resistance of AML to allogeneic hematopoietic stem cell transplantation and demonstrates the potential of targeting SOCS1 and its downstream mediators to enhance antileukemic T-cell activity. See related commentary by Fry, p. 157.

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