We studied the age- and genetic-related prevalence of CSF alpha-Synuclein seeding and Alzheimer profiles in 188 samples from PD participants without GBA1 variants (PD(wildtype)) and in 129 samples from PD participants with GBA1 variants (PD(GBA1)). While Alzheimer profiles increased with age in PD(wildtype), it was sparse in PD(GBA1). Alpha-Synuclein profiles remained stable with age in both cohorts. In PD(wildtype), combined alpha-Synuclein/Alzheimer profiles were associated with earlier onset of cognitive impairment.
Differences in age-related distribution of CSF alpha-synuclein seeding and Alzheimer profiles between PD with and without GBA1 variants.
GBA1 变异型帕金森病患者与非帕金森病患者在脑脊液 α-突触核蛋白播散和阿尔茨海默病特征的年龄相关分布方面存在差异
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作者：Lerche Stefanie, Wurster Isabel, Roeben Benjamin, Zimmermann Milan, Rossi Marcello, Mammana Angela, Baiardi Simone, Hauser Ann-Kathrin, Deuschle Christian, Schulte Claudia, Parchi Piero, Brockmann Kathrin
| 期刊： | Npj Parkinsons Disease | 影响因子： | 8.200 |
| 时间： | 2025 | 起止号： | 2025 May 5; 11(1):107 |
| doi： | 10.1038/s41531-025-00978-1 | 研究方向： | 免疫/内分泌 |
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