Importance of Toll-like receptor 9 in host defense against M1T1 group A Streptococcus infections.

Toll 样受体 9 在宿主防御 M1T1 A 组链球菌感染中的重要性

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作者:Zinkernagel Annelies S, Hruz Petr, Uchiyama Satoshi, von Köckritz-Blickwede Maren, Schuepbach Reto A, Hayashi Tomoko, Carson Dennis A, Nizet Victor
Timely recognition and elimination of invasive group A Streptococcus (GAS) by innate immunity is crucial to control infection. The intracellular pattern recognition receptor Toll-like receptor 9 (TLR9) promotes macrophage hypoxia-inducible factor-1α levels, oxidative burst and nitric oxide production in response to GAS. TLR9 contributes to GAS clearance in vivo in both localized cutaneous and systemic infection models.

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