Full-Thickness Heart Repair with an Engineered Multilayered Myocardial Patch in Rat Model
使用工程多层心肌补片修复大鼠全层心脏
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作者：Seokwon Pok, Igor V Stupin, Christopher Tsao, Robia G Pautler, Yang Gao, Raymond M Nieto, Ze-Wei Tao, Charles D Fraser Jr, Ananth V Annapragada, Jeffrey G Jacot
Abstract
In a rat model of right free wall replacement, the transplantation of an engineered multilayered myocardial patch fabricated from a polycaprolactone membrane supporting a chitosan/heart matrix hydrogel induces significant muscular and vascular remodeling and results in a significantly higher right ventricular ejection fraction compared to use of a commercially available pericardium patch.
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