Serosurveillance of dengue infection and correlation with mosquito pools for dengue virus positivity during the COVID-19 pandemic in Tamil Nadu, India - A state-wide cross-sectional cluster randomized community-based study

印度泰米尔纳德邦 COVID-19 疫情期间登革热感染血清监测及与蚊子聚集区登革热病毒阳性率的相关性 - 一项全州范围的横断面集群随机社区研究

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作者:Sivaprakasam T Selvavinayagam, Sathish Sankar, Yean K Yong, Abdul R Anshad, Samudi Chandramathi, Anavarathan Somasundaram, Sampath Palani, Parthipan Kumarasamy, Roshini Azhaguvel, Ajith B Kumar, Sudharshini Subramaniam, Manickam Malathi, Venkatachalam Vijayalakshmi, Manivannan Rajeshkumar, Anandhazh

Background

Dengue is a vector-borne viral disease impacting millions across the globe. Nevertheless, akin to many other diseases, reports indicated a decline in dengue incidence and seroprevalence during the COVID-19 pandemic (2020-22). This presumably could be attributed to reduced treatment-seeking rates, under-reporting, misdiagnosis, disrupted health services and reduced exposure to vectors due to lockdowns. Scientific evidence on dengue virus (DENV) disease during the COVID-19 pandemic is limited globally.

Methods

A cross-sectional, randomized cluster sampling community-based survey was carried out to assess anti-dengue IgM and IgG and SARS-CoV-2 IgG seroprevalence across all 38 districts of Tamil Nadu, India. The prevalence of DENV in the Aedes mosquito pools during 2021 was analyzed and compared with previous and following years of vector surveillance for DENV by real-time PCR. Findings:

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