Comparative population analysis of Klebsiella pneumoniae strains with extended-spectrum β-lactamases colonizing patients in rehabilitation centers in four countries

四国康复中心患者中含超广谱 β-内酰胺酶肺炎克雷伯菌菌株的比较群体分析

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作者:A Baraniak, R Izdebski, J Fiett, E Sadowy, A Adler, M Kazma, J Salomon, C Lawrence, A Rossini, A Salvia, J Vidal Samso, J Fierro, M Paul, Y Lerman, S Malhotra-Kumar, C Lammens, H Goossens, W Hryniewicz, C Brun-Buisson, Y Carmeli, M Gniadkowski; MOSAR WP2 and WP5 Study Groups

Abstract

The international project MOSAR was conducted in five rehabilitation centers; patients were screened for rectal carriage of extended-spectrum β-lactamase (ESBL)-producing members of the Enterobacteriaceae. Among 229 Klebsiella pneumoniae isolates, four clonal groups (CG) or complexes (CC) prevailed: CG17 in France, CG101 in Italy, CG15 in Spain, and CC147 in Israel. ESBLs, mainly CTX-Ms, were produced by 226 isolates; three isolates expressed AmpC-like cephalosporinases. High genetic diversity of K. pneumoniae populations was observed, with specific characteristics at each center.

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