Local hyperthermia treatment of tumors induces CD8(+) T cell-mediated resistance against distal and secondary tumors

肿瘤局部热疗可诱导 CD8(+) T 细胞介导对远端和继发性肿瘤的抵抗

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作者:Seiko Toraya-Brown #, Mee Rie Sheen #, Peisheng Zhang, Lei Chen, Jason R Baird, Eugene Demidenko, Mary Jo Turk, P Jack Hoopes, Jose R Conejo-Garcia, Steven Fiering

From the clinical editor

Local heating of tumors via iron oxide NPs and an alternating magnetic field led to activation of anti-cancer CD8 T cells, which resulted in resistance against re-challenge and greater resistance to secondary tumors. Similar local heating-based strategies may become an important weapon in enhancing tumor elimination via a naturally existing but attenuated immune response.

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