Drosophila protamine-like Mst35Ba and Mst35Bb are required for proper sperm nuclear morphology but are dispensable for male fertility

果蝇鱼精蛋白样 Mst35Ba 和 Mst35Bb 是维持精子核正常形态所必需的,但对雄性生育力而言并非必需

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作者:Samantha Tirmarche, Shuhei Kimura, Laure Sapey-Triomphe, William Sullivan, Frédéric Landmann, Benjamin Loppin

Abstract

During spermiogenesis, histones are massively replaced with protamines. A previous report showed that Drosophila males homozygous for a genomic deletion covering several genes including the protamine-like genes Mst35Ba/b are surprisingly fertile. Here, we have precisely deleted the Mst35B locus by homologous recombination, and we confirm the dispensability of Mst35Ba/b for fertility.

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