This study reveals a broad convergence in genetic adaptation to hypoxia between natural populations and tumors, suggesting that insights from natural populations could enhance our understanding of cancer biology and identify novel therapeutic targets. See related commentary by Lee, p. 875.
Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes.
在全身缺氧和高海拔地区人群中，人类肿瘤的趋同遗传适应
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作者：Arenillas Carlota, Celada LucÃa, Ruiz-Cantador José, Calsina Bruna, Datta Debayan, GarcÃa-Galea Eduardo, Fasani Roberta, Moreno-Cárdenas Ana Belén, Alba-Linares Juan José, Miranda-Barrio Berta, MartÃnez-Montes Ãngel M, Alvarez-Escola Cristina, Lecumberri Beatriz, González GarcÃa Ana, K Flores Shahida, Esquivel Emmanuel, Ding Yanli, Peitzsch Mirko, Robles-Guirado José-Ãngel, Regojo Zapata Rita Maria, Pozo-Kreilinger José Juan, Iglesias Carmela, Dwight Trisha, Muir Christopher A, Oleaga Amelia, Garrido-Lestache RodrÃguez-Monte Maria Elvira, Del Cerro Maria Jesús, MartÃnez-Bendayán Isaac, Ãlvarez-González Enol, Cubiella Tamara, Lourenço Delmar Muniz Jr, A Pereira Maria Adelaide, Burnichon Nelly, Buffet Alexandre, Broberg Craig, Dickson Paxton V, Fraga Mario F, Llorente Pendás José Luis, Rueda Soriano JoaquÃn, BuendÃa Fuentes Francisco, Toledo Sergio P A, Clifton-Bligh Roderick, Dienstmann Rodrigo, Villanueva Josep, Capdevila Jaume, Gimenez-Roqueplo Anne-Paule, Favier Judith, Nuciforo Paolo, Young William F Jr, Bechmann Nicole, Opotowsky Alexander R, Vaidya Anand, Bancos Irina, Weghorn Donate, Robledo Mercedes, Casterà s Anna, Dos-Subirà Laura, Adameyko Igor, Chiara MarÃa-Dolores, Dahia Patricia L M, Toledo Rodrigo A
| 期刊： | Cancer Discovery | 影响因子： | 33.300 |
| 时间： | 2025 | 起止号： | 2025 May 2; 15(5):1037-1062 |
| doi： | 10.1158/2159-8290.CD-24-0943 | 种属： | Human |
| 研究方向： | 肿瘤 | ||
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