This study reveals a broad convergence in genetic adaptation to hypoxia between natural populations and tumors, suggesting that insights from natural populations could enhance our understanding of cancer biology and identify novel therapeutic targets. See related commentary by Lee, p. 875.
Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes
在全身性缺氧和高海拔地区人群中，人类肿瘤的趋同遗传适应
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作者：Carlota Arenillas ,Lucía Celada ,José Ruiz-Cantador ,Bruna Calsina ,Debayan Datta ,Eduardo García-Galea ,Roberta Fasani ,Ana Belén Moreno-Cárdenas ,Juan José Alba-Linares ,Berta Miranda-Barrio ,Ángel M Martínez-Montes ,Cristina Alvarez-Escola ,Beatriz Lecumberri ,Ana González García ,Shahida K Flores ,Emmanuel Esquivel ,Yanli Ding ,Mirko Peitzsch ,José-Ángel Robles-Guirado ,Rita Maria Regojo Zapata ,José Juan Pozo-Kreilinger ,Carmela Iglesias ,Trisha Dwight ,Christopher A Muir ,Amelia Oleaga ,Maria Elvira Garrido-Lestache Rodríguez-Monte ,Maria Jesús Del Cerro ,Isaac Martínez-Bendayán ,Enol Álvarez-González ,Tamara Cubiella ,Delmar Muniz Lourenço Jr ,Maria Adelaide A Pereira ,Nelly Burnichon ,Alexandre Buffet ,Craig Broberg ,Paxton V Dickson ,Mario F Fraga ,José Luis Llorente Pendás ,Joaquín Rueda Soriano ,Francisco Buendía Fuentes ,Sergio P A Toledo ,Roderick Clifton-Bligh ,Rodrigo Dienstmann ,Josep Villanueva ,Jaume Capdevila ,Anne-Paule Gimenez-Roqueplo ,Judith Favier ,Paolo Nuciforo ,William F Young Jr ,Nicole Bechmann ,Alexander R Opotowsky ,Anand Vaidya ,Irina Bancos ,Donate Weghorn ,Mercedes Robledo ,Anna Casteràs ,Laura Dos-Subirà ,Igor Adameyko ,María-Dolores Chiara ,Patricia L M Dahia ,Rodrigo A Toledo
| 期刊： | Cancer Discovery | 影响因子： | 29.700 |
| 时间： | 2025 | 起止号： | 2025 May 2;15(5):1037-1062. |
| doi： | 10.1158/2159-8290.CD-24-0943 | 种属： | Human |
| 研究方向： | 肿瘤 | ||
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