This study investigates the role of c-FLIP in sepsis-induced myocardial dysfunction (SIMD), focusing on cardiac microcirculation and mitochondrial autophagy. Using SIMD rat and LPS-induced cardiac microvascular endothelial cell injury models, we found that c-FLIP deficiency disrupts mitochondrial homeostasis, exacerbating microcirculatory damage. c-FLIP differentially regulates mitochondrial autophagy via FUNDC1. Overexpression of c-FLIP balances autophagy, protects mitochondria, reduces inflammation, and ameliorates SIMD, highlighting its potential as a therapeutic target.
c-FLIP Protects Cardiac Microcirculation in Sepsis-Induced Myocardial Dysfunction Via FUNDC1-Mediated Regulation of Mitochondrial Autophagy.
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作者：Gao Lan, Shi Qindong, Sun Bin, Zhang Xiaoyu, Zheng Peiying, Zhou Linjing, Tian Gang, Li Hao
| 期刊： | Jacc-Basic To Translational Science | 影响因子： | 7.200 |
| 时间： | 2025 | 起止号： | 2025 Aug;10(8):101257 |
| doi： | 10.1016/j.jacbts.2025.02.016 | ||
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